Nicotine in the blood

Nicotine - 1-methyl-2 (3-pyridyl) - Pyrrolidine - an organic compound, an alkaloid naturally found in tobacco plants - one of the strongest neurotic poison. Nicotine is synthesized Raknes and accumulated in leaves, resulting in them are found only significant concentration of nicotine. Physical properties: colorless, volatile, liquid, characteristic odor, brown in the air.
Effects
1. Carcinogenic effects. Nicotine affects other toxic chemicals found in tobacco smoke, a negative carcinogenic effects, by inhibiting the body's reaction to the potential destruction of tumor cells. Direct effect on healthy cells do not have a rollover cancer nicotine.
2nd Stimulation effect. Nicotine causes an influx of energy, helps with concentration, increases alertness, improves eye and hand coordination, memory, stimulates the sympathetic nervous system, coronary heart blood vessels to collapse. Nicotine stimulates the adrenal cortex, increases the adrenaline and noradrenalin Breakdown. As a consequence - increased heart beat, increased blood pressure, minutely soul is, cardiac work and oxygen consumption mmiokarde. Smokers break 10-20 heart beats per minute, so a year in smoking among human heart shake 5-10 million times more than non-smokers the human heart. Peripheral vascular BAI is rapidly absorbed and pulmonary capillary wedge within a few seconds to produce high concentrations in the brain. During the oral mucous membrane, nicotine is absorbed slowly and incomplete. After 6-8 hours nicotine levels by 75%. When a man strongly felt by withdrawal symptoms. (anxiety, tension, irritability, depression, volatile moods, fatigue, sleep disturbances, impaired concentrating, increased appetite, weight gain, perspiration, chills, headache, dizziness. - accessories). Increases your heart rate, blood pressure and decreases appetite. At high doses, causing vomiting and nausea. Adults lethal dose of nicotine - 40-60mg.
3rd Dependence. Causes nikotinizma - addiction to nicotine. (Lack of nicotine (withdrawal) symptoms include irritability, headache, anxiety, sleep disorders. Symptomatic 2-6 weeks, I felt 48-72 hours after the last dose of nicotine.) Nicotine inhaled into the lungs with tobacco smoke is low (about 10mg), but it is enough to cause addiction.
4th Nicotine to enter the body enough to 7 seconds on the circulatory system achieve barrier brain and spread to the brain.
5th Nicotine raises dopamine smooth.
Pipe and cigar nicotine more than cigarettes, but their heavy smoke intensely irritating to respiratory tract, resulting in less smoke (including nicotine and inhalation. Cigarette smoke is lighter and less nicotine inhalation. A standard cigarette is about 20mg of nicotine. Part of nicotine break down from heat, part -- dissipates in the environment. into the body from falling on 2mg. lethal dose of the human body is 1 mg nicotine per kilogram of body weight.
Cigarettes with lower nicotine and tar yield is also harmful to humans. The organism tries to maintain a certain nicotine levels in the blood, so smoking "lighter" cigarettes, people include a deeper and more imbue carbon monoxide and other harmful substances.